CohesinDB v1.5 update: (start from Jan 1, 2026)

Building upon our previously developed multiomics resource CohesinDB, we mapped TF binding to cohesin-associated regulatory sites and linked these sites to their downstream target genes. The resulting Cohesin-GRN module in CohesinDB comprises 61,222,502 TF–cohesin site links and 2,228,634 cohesin site–gene links, collectively forming over 270 million TF–site–gene regulatory paths.

By enabling a CRE-informed and site-aware representation of gene regulation, Cohesin-GRN bridges conventional TF–gene GRNs with regulatory site-centric mechanisms. Given the pervasive roles of cohesin in enhancer activity, transcriptional control, and human disease, Cohesin-GRN provides a valuable resource for exploring transcriptional dysregulation and gene regulatory networks.